2017年–2020年 东京大学 应用生命化学 博士

2013年–2016年 浙江大学 农业与生物技术学院 硕士

2024年–至今 浙江大学长三角智慧绿洲创新中心 特聘研究员

2020年–2023年  东京大学 助理教授

1. 2025/01/06－2025/07/22Topic editor, Exploring Post-Translational Modifications in Food-Derived Proteins, Frontiers in Nutrition

2. 2023/02/10－2023/12/20Topic Coordinator, Novel Analytical Technologies and Chemometrics: Quality and Structural Biological Analysis of Agri-food Components, Frontiers in Nutrition

3. 2023/11Peer Reviewer, Journal of Agricultural and Food Chemistry

4. 2019/08Peer Reviewer, Journal of Functional Foods

科研项目：

1. 2025/01/01－2026/12/31　副溶血弧菌周质空间铁结合蛋白的结构功能解析及抑制剂开发｜浙江省自然科学基金｜青年基金项目（LQN25C050002）

2. 2024/04/01－2027/03/31　柑橘果皮フラボノイドによる長寿遺伝子産物SIRT1活性調節及び抗老化機能の研究｜LOTTE Foundation｜11th Lotte Research Promotion Grant

3. 2023/04/01－2024/03/31　海洋ビブリオ属細菌の鉄捕捉タンパク質の構造機能解析及び鉄制限を用いる抗菌剤探索｜Japan Science Society｜Sasakawa Scientific Research Grant（2023-4016）

4. 2020/09/11－2022/03/31Structural and functional studies of iron uptake ATP-binding cassette transporters (ABC transporters) in Gram-negative bacteria｜Japan Society for the Promotion of Science (JSPS)｜Grants-in-Aid for Scientific Research（20K22561）

论文发表：

主要论文:

1. Zhang, M.-M., Chen, W.-Z., Zhang, L.-P.*, & Lu, P.* (2025). Knockout mutation to enhance sophorolipid production in Starmerella bombicola based on computational structural analysis of fatty acid oxidation enzymes. International Journal of Biological Macromolecules, 307, 142104
https://doi.org/10.1016/j.ijbiomac.2025.142104

2. Jiang, J., Okuda, S., Itoh, H., Okamoto, K., Nakanishi, H., Suzuki, M., Lu, P.*, & Nagata, K.* (2024). Structure-guided discovery of a potent inhibitor of the ferric citrate binding protein FecB in Vibrio bacteria. Angewandte Chemie, Dec 16;63(51):e202411688.
https://doi.org/10.1002/ange.202411688 | (PDB: 8Y5A, 8Y4V, 8Y4Y)

3. Lu, P.*, & Wang, M. (2024). The future of food science: Embracing genetic modification and biosynthesis in the face of global warming. Future Postharvest and Food,1–4.
https://doi.org/10.1002/fpf2.12005

4. Lu, P.*, Jiang, J., Liu, C., Okuda, S., Itoh, H., Okamoto, K., Suzuki, M., & Nagata, K.* (2023). Molecular mechanism of Fe³⁺ binding inhibition to Vibrio metschnikovii ferric ion-binding protein, FbpA, by rosmarinic acid and its hydrolysate, danshensu. Protein Science, 024;33(2):e4881.
https://doi.org/10.1002/pro.4881 | (PDB: 8J4J, 8J4H)

5. Lu, P., Zhou, J., Wei, S., Takada, K., Masutani, H., Okuda, S., Okamoto, K., Suzuki, M., Kitamura, T., Masujin, K., Kokuho, T., Itoh, H., & Ngata K.* (2023). Comparative genomic and transcriptomic analyses of African swine fever virus strains. Computational and Structural Biotechnology Journal, 21, 4322–4335.
https://doi.org/10.1016/j.csbj.2023.08.028

6. Lu, P., Takiguchi, S., Honda, Y., Lu, Y., Mitsui, T., Kato, S., Kodera, R., Furihata, K., Zhang, M., Okamoto, K., Itoh, H., Suzuki, M., Kono, H., & Nagata, K.* (2022). NMR and HPLC profiling of bee pollen products from different countries. Food Chemistry: Molecular Sciences, 5, 100119.
https://doi.org/10.1016/j.fochms.2022.100119

7. Lu, P.*, Sui, M., Zhang, M., Wang, M., Kamiya, T., Okamoto, K., Itoh, H., Okuda, S., Suzuki, M., Asakura, T., Fujiwara, T., & Nagata, K.* (2021). Rosmarinic acid and sodium citrate have a synergistic bacteriostatic effect against Vibrio species by inhibiting iron uptake. International Journal of Molecular Sciences, 22(23), 13010.
https://doi.org/10.3390/ijms222313010 | (PDB: 7W3W)

8. Lu, P., Moriwaki, Y., Zhang, M., Katayama, Y., Lu, Y., Okamoto, K., Terada, T., Shimizu, K., Wang, M., Kamiya, T., Fujiwara, T., Asakura, T., Suzuki, M., Yoshimura, E., & Nagata, K.* (2019). Functional characterisation of two ferric-ion coordination modes of TtFbpA, the periplasmic subunit of an ABC-type iron transporter from Thermus thermophilus HB8. Metallomics, 11(12), 2078–2088.
https://doi.org/10.1039/c9mt00245f 

共作论文:

1. Liu, C., Tang, J., Lu, P., Takabayashi, S., Yagaki, D., Tsutsumi, K., Okuda, S., Itoh, H., Matsukura, H., Toyota, S., Shimokawa, M., Suzuki, K., & Nagata, K. (2026). Natural food-derived antimicrobials against beer spoilage microorganisms. Applied Microbiology and Biotechnology, 110(1), 101.
https://doi.org/10.1007/s00253-026-13787-0

2. Wei, S., Lu, P., Miyata, T., Makino, F., Namba, K., Liu, C., Niu, Y., Saito, S., Okuda, S., Tsutsumi, K., Okamoto, K., Suzuki, M., Kitamura, T., Masujin, K., Kokuho, T., Itoh, H.*, Nagata, K.*, (2026). African swine fever virus protein pB602L is a unique molecular chaperone promoting the folding of the major capsid protein p72 and the polyprotein processing protease pS273R. International Journal of Biological Macromolecules 347, 150685. https://doi.org/10.1016/j.ijbiomac.2026.150685

3. Lu, Y., Ito, M., Makino, K., Sumida, T., Honda, Y., Takiguchi, S., Benea, M. A., Lu, P., Katayama, Y., Okamoto, K., Itoh, H., Okuda, S., Suzuki, M., Furihata, K., & Nagata, K.* (2026). Rapid, non-destructive and comprehensive quantitative analysis of honey by combined use of conventional and broadband-WET NMR spectra. Food Chemistry, 501, 147610. https://doi.org/10.1016/j.foodchem.2025.147610

4. Namikawa, Y., Zhu, L., Lu, P., Nagata, K., & Suzuki, M. (2025)*. Calcium dissociation with carbonate ions from Pf‐ SCP , sarcoplasmic calcium‐binding protein in Pinctada fucata , contributes to calcium mineralization for shell formation. Protein Science, 34(11), e70336.
https://doi.org/10.1002/pro.70336 | (PDB: 9L5M)

5. Zheng, Z., Namikawa, Y., Kato, Y., Lu, P., Negishi, L., Kurumizaka, H., Nagata, K., & Suzuki, M.* (2025). Exploring cadmium-binding proteins in Japanese scallops Mizuhopecten yessoensis: isolation and characterization. Environmental science and pollution research international, 32(31), 18961–18974.
https://doi.org/10.1007/s11356-025-36799-1

6. Wang, T., Yang, X., Lu, P., Wang, W., Gao, A., Cai, Z.*, & Liu, D.* (2025). Myofibrillar protein and sunflower pectin complex for oil-in-water emulsion: Characteristics, interactions, and mechanisms. Food Chemistry, 492, 145589.
https://doi.org/10.1016/j.foodchem.2025.145589

7. Jiang, N., Bao, H., Lu, P., Li, Q., Liu, D., & Chen, Q. (2025). Natural polyphenols naringin targeting GSK3β: An effective strategy for enhancing myoblast proliferation and myogenesis for cultured meat production. Food Bioscience, 69, 106875. 
https://doi.org/10.1016/j.fbio.2025.106875

8. Wei, S., Li, L., Lu, P., Suzuki, M., Okuda, S., Okamoto, K., Itoh, H. and Nagata, K., 2025. Identification of a novel subtilisin-derived peptide, SC-(1-31), with cytotoxic activity. Biochemical and Biophysical Research Communications, p.151101. Jan;742:151101. 
https://doi.org/10.1016/j.bbrc.2024.151101

9. Zhou, X., Wang, J., Wang, H., Lu, P., Huang, Q., Huang, M., Lv, R., Liu, D., & Wang, W. (2024). Identification of extracted antioxidants from Citrus aurantium ‘Changshanhuyou’ residue against digestive enzyme activities and airway smooth muscle cells proliferation using UPLC-MS/MS. Food Bioscience, 61, 104910. 
https://doi.org/10.1016/j.fbio.2024.10491

10. Watabe, S., Mizusawa, N., Hosaka, K., Ishizaki, S., Lu, P., Nagata, K., & Ueki, N. (2024). Molecular Localization of Health-Promoting Peptides Derived from Fish Protein Hydrolyzates on Fish Muscle Proteins. Marine Biotechnology (New York, N.Y.).
https://doi.org/10.1007/s10126-024-10331-x

11. Zhu, W., Wu, Y., Li, C., Li, X., Li, K., Yang, W., Liang, Y., Lu, J., Zhang, L., Lu, P., & Zheng, X. (2024). Metabolomics and quantitative descriptive analysis reveal the relationship between metabolites and taste attributes of flowers in two types of albino tea cultivars. LWT, 116074.
https://doi.org/10.1016/j.lwt.2024.116074

12. Narita, Y., Tamura, A., Hatakeyama, S., Uemura, S., Miura, A., Haga, A., Tsuji, N., Fujie, N., Izumi, Y., Sugawara, T., Otaka, M., Okamoto, K., Lu, P., Okuda, S., Suzuki, M., Nagata, K., Shimizu, H., & Itoh, H. (2024). The components of the AhR-molecular chaperone complex differ depending on whether the ligands are toxic or non-toxic. FEBS letters, 598(12), 1478–1490.
https://doi.org/10.1002/1873-3468.14871

13. Anan, Y., Itakura, M., Shimoda, T., Yamaguchi, K., Lu, P., Nagata, K., Dong, J., Ueda, H., & Uchida, K. (2024). Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins. Communications Biology, 7(1), 149.
https://doi.org/10.1038/s42003-024-05851-0 (PDB: 8HYL)

14. Zhang, C., Lu, P., Wei, S., Hu, C., Miyoshi, M., Okamoto, K., Itoh, H., Okuda, S., Suzuki, M., Kawakami, H., & Nagata, K.* (2024). Refolding, crystallization, and crystal structure analysis of a scavenger receptor cysteine-rich domain of human salivary agglutinin expressed in Escherichia coli. The Protein Journal. Apr;43(2):283-297.
https://doi.org/10.1007/s10930-023-10173-x (PDB: 8WZS, 8J8D)

15. Ye, J., Lin, X., Yang, Z., Wang, Y., Liang, Y., Wang, K., Lu, J., Lu, P., & Zheng, X.* (2024). The light-harvesting chlorophyll a/b-binding proteins of photosystem II family members are responsible for temperature sensitivity and leaf color phenotype in albino tea plant. Journal of Advanced Research. Dec;66:87-104.
https://doi.org/10.1016/j.jare.2023.12.017

16. Noguchi, M., Shimizu, M.*, Lu, P., Takahashi, Y., Yamauchi, Y., Sato, S., Kiyono, H., Kishino, S., Ogawa, J., Nagata, K., & Sato, R.* (2022). Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids. Journal of Biological Chemistry, 298(11), 102534.
https://doi.org/10.1016/j.jbc.2022.102534

17. Zhang, M., Lu, P., Terada, T., Sui, M., Furuta, H., Iida, K., Katayama, Y., Lu, Y., Okamoto, K., Suzuki, M., Asakura, T., Shimizu, K., Hakuno, F., Takahashi, S.-I., Shimada, N., Yang, J., Ishikawa, T., Tatsuzaki, J., & Nagata, K.* (2021). Quercetin 3,5,7,3’,4’-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1. Communications Biology, 4(1), 209.
https://doi.org/10.1038/s42003-021-01705-1

18. Zhu, L., Wang, L., Matsuura, A., Zhang, M., Lu, P., Iimura, K., Nagata, K., & Suzuki, M.* (2021). Purification, crystallization and X-ray analysis of Pf-SCP (sarcoplasmic Ca-binding protein), related to storage and transport of calcium in mantle of Pinctada fucata. Protein Expression and Purification, 178, 105781.
https://doi.org/10.1016/j.pep.2020.105781

19. Lu, Y., Wang, Y., Huang, D., Bian, Z., Lu, P., Fan, D., & Wang, X.* (2021). Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea. Journal of Zhejiang University. Science. B, 22(7), 575–589.
https://doi.org/10.1631/jzus.B2000520

20. Lu, Y., Lu, P., Wang, Y., Fang, X., Wu, J., & Wang, X.* (2019). A novel dipeptidyl peptidase IV inhibitory tea peptide improves pancreatic β-cell function and reduces α-cell proliferation in streptozotocin-induced diabetic mice. International Journal of Molecular Sciences, 20(2), E322.
https://doi.org/10.3390/ijms20020322

著作：

《吃货科学指南》汪诘, 陆鹏 著. 海南出版社出版.

主持庆元县“山海协”项目，完成“香菇粉酶解技术的研发及中式放大”。

服务某乳制品龙头企业，完成“乳清蛋白微粒化蛋白结构的研究”。

服务某日化龙头企业，完成“酶分子立体结构及酶-底物分子动力学分析”。

2025年 浙江省“引才计划” 青年人才 【省级】

2025年 嘉兴市“星耀南湖”创新、创业领军人才 【市级】

2025年 第九届“红船杯”嘉兴全球创业大赛总决赛 三等奖/博士后创业赛 二等奖【市级】

2022年 获英国皇家化学学会 Molecular Omics Award【国际】

2020年 获东京大学 The Dean Award for Academic Excellence【国际】