2015—2021 浙江大学 中药科学与工程学系 药物分析学 博士（导师：范骁辉）

2011—2015 浙江大学 药学院 药学 学士

2023—迄今  浙江大学 长三角智慧绿洲创新中心  “百人计划”研究员

2022—2023 浙江大学 医学院附属杭州市第一人民医院  助理研究员

2021—2023 浙江大学 医学院附属杭州市第一人民医院  消化内科博士后（导师：徐骁）

担任世界中医药学会联合会网络药理学专委会理事、中国药理学会网络药理学会青委会委员及Gut Medicine、Chin J Nat Med、The Innovation Drug Discovery等期刊青年编委。

主要研究方向

1. 基于单细胞时空组学的细胞间通讯网络推断方法研究

2. 酒精性、脂肪性、缺血再灌注肝损伤与修复机制研究

3. 基于人工智能的中药新药智能发现及组方优化

主要研究成果

• Tan S#, Shao X#*, Zhang X, Dai Y, Zhang B*, Cheng Y*, Fan X*. TCMNet: an AI-driven strategy for optimizing traditional Chinese medicine. Chin Med. 2026 March 31;21:106. doi: 10.1186/s13020-026-01360-w.

• Qian J, Bao H, Yang H, Zhang J, Shao X*, Fan X*. AI-driven deciphering of cell niches with single-cell and spatial omics: a new perspective for traditional Chinese medicine research. Targetome (Cover). 2026 Feb 26;2(2):e009. doi: 10.48130/targetome-0026-0009.

• Zhang J#, Zhang X#, Dai Y#, Shao X*, Fan X*. Transformer-based graphs for drug-drug interaction with chemical knowledge embedding. Brief Bioinform. 2026 Jan 7;27(1):bbag039. doi: 10.1093/bib/bbag039.

• Wang T#, Hu Y#, Guo W#, Li H, Wang M, Chen B, Bao H, Gao M, Li X, Chen Q, Shen M, Shao X*, Liao J*, Fan X*. An integrated resource for ischemic heart disease defines hallmarks and heterogeneity across time and space. Acta Pharm Sin B. 2026 Jan;16(1):642-646. doi: 10.1016/j.apsb.2025.11.020.

• Shao X*, Chen Y, Zhang J, Zhang X, Dai Y, Peng X*, Fan X*. Advancing network pharmacology with artificial intelligence: the next paradigm in traditional Chinese medicine. Chin J Nat Med (Cover). 2025 Nov;23(11):1358-1376. doi: 10.1016/S1875-5364(25)60941-1.

• Chen R, Yao Y, Qian J, Peng X*, Shao X*, Fan X*. A comprehensive benchmarking for spatially resolved transcriptomics clustering methods across variable technologies, organs, and replicates. iMeta. 2025 Oct 9;4(6):e70084. doi: 10.1002/imt2.70084.

• Wang K#, Wang Z#, Shao X#, Meng L#, Liu C, Qiu N, Ge W, Chen Y, Tang X, Wang X, Lian Z, Zhou R, Zheng S, Fan X*, Xu X*. Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation. Acta Pharm Sin B. 2025 Oct;15(10):5277-5293. doi: 10.1016/j.apsb.2025.07.042.

• Shao X#*, Yu L#, Li C, Qian J, Yang X, Yang H, Liao J, Fan, X, Xu X*, Fan X*. Extracellular vesicle-derived miRNA-mediated cell-cell communication inference for single-cell transcriptomic data with miRTalk. Genome Biol. 2025 April 14;26:95. doi: 10.1186/s13059-025-03566-x.

• Qian J#, Shao X#*, Bao H#, Fang Y, Guo W, Li C, Li A, Hua H*, Fan X*. Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution. Nat Commun (Editor Highlights). 2025 Feb 16;16(1):1693. doi: 10.1038/s41467-025-57029-9.

• Sun F#, Li H#, Sun D#, Fu S#, Gu L#, Shao X#, Wang Q#, Dong X#, Duan B#, Xing F#, Wu J#, Xiao M*, Zhao F*, Han JJ*, Liu Q*, Fan X*, Li C*, Wang C*, Shi T*. Single-cell omics: experimental workflow, data analyses and applications. Sci China Life Sci (Cover). 2025 Jan;68(1):5-102. doi: 10.1007/s11427-023-2561-0.

• Dai Y#, Shao X#*, Zhang J#, Chen Y, Chen Q, Liao J, Chi F, Zhang J*, Fan X*. TCMChat: A generative large language model for traditional Chinese medicine. Pharmacol Res. 2024 Dec;210:107530. doi: 10.1016/j.phrs.2024.107530.

• Li C#, Shao X#*, Zhang S, Wang Y, Jin K, Yang P, Lu X, Fan X*, Wang Y*. scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network. Cell Rep Med. 2024 Jun 18;5(6):101568. doi: 10.1016/j.xcrm.2024.101568.

• Shao X#, Wang Z#, Wang K#, Lu X#, Zhang P, Guo R, Liao J, Yang P, Zheng S, Xu X*, Fan X*. A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction. Engineering. 2024 May;36:193-208. doi: 10.1016/j.eng.2023.12.004.

• Shao X#, Li C#, Yang H#, Lu X, Liao J, Qian J, Wang K, Cheng J, Yang P, Chen H*, Xu X*, Fan X*. Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk. Nat Commun (Editor Highlights). 2022 Jul 30;13(1):4429. doi: 10.1038/s41467-022-32111-8.

• Shao X#, Yang H#, Zhuang X, Liao J, Yang P, Cheng J, Lu X, Chen H*, Fan X*. scDeepSort: a pre-trained cell-type annotation method for single-cell transcriptomics using deep learning with a weighted graph neural network. Nucleic Acids Res. 2021 Dec 2;49(21):e122. doi: 10.1093/nar/gkab775.

• Shao X#, Liao J#, Li C#, Lu X, Cheng J, Fan X*. CellTalkDB: a manually curated database of ligand-receptor interactions in humans and mice. Brief Bioinform (ESI highly cited paper). 2021 Jul 20;22(4):bbaa269. doi: 10.1093/bib/bbaa269.

• Shao X#, Lu X#, Liao J, Chen H, Fan X*. New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data. Protein Cell. 2020 Dec;11(12):866-880. doi: 10.1007/s13238-020-00727-5.

• Shao X#, Wang Y#, Lu X#, Hu Y, Liao J, Li J, Chen X, Yu Y, Ai N, Ying M, Fan X*. A Clinical Genomics-Guided Prioritizing Strategy Enables Selecting Proper Cancer Cell Lines for Biomedical Research. iScience. 2020 Oct 28;23(11):101748. doi: 10.1016/j.isci.2020.101748.

• Shao X, Liao J, Lu X, Xue R, Ai N, Fan X*. scCATCH: Automatic Annotation on Cell Types of Clusters from Single-Cell RNA Sequencing Data. iScience. 2020 Mar 27;23(3):100882. doi: 10.1016/j.isci.2020.100882.

• Shao X, Lv N, Liao J, Long J, Xue R, Ai N, Xu D*, Fan X*. Copy number variation is highly correlated with differential gene expression: a pan-cancer study. BMC Med Genet. 2019 Nov 9;20(1):175. doi: 10.1186/s12881-019-0909-5.

• Shao X, Ai N*, Xu D*, Fan X. Exploring the interaction between Salvia miltiorrhiza and human serum albumin: Insights from herb-drug interaction reports, computational analysis and experimental studies. Spectrochim Acta A Mol Biomol Spectrosc. 2016 May 15;161:1-7. doi: 10.1016/j.saa.2016.02.015.

泽济智药（嘉兴）科技有限公司联合创始人，与康恩贝、青春宝、杭州市中医院等中医药龙头企业及医院共同开展了多个临床验方/协定方优化，推动系列中药院内制剂及中药新药转化。

作为主要完成人获浙江省科学技术进步一等奖、华夏医学科学技术一等奖、中医药十大学术进展、浙江省工程科技创新十大案例等。