Currently, Prof. Chenis serving as PI of Genomic Medicine Laboratory in Innovation Center of Yangtze River Delta, Zhejiang University. He started scientific career in The University of Tokyo, under supervision of Prof. Kazunori Kataoka (US National Academician of Engineering), working on manufacture of intelligent nanocapsules capable of overcoming a string of biological barriers that hinder delivery of therapeutic gene into the targeted cell interiors. Furthermore, he moved to Massachusetts Institute of Technology as postdoctoral associate in Jeremiah A. Johnson Laboratory to pursue development and translation of novel chemistry (particularly ring-opening metathesis polymerization) into biomedical applications. He started independent research in Dalian University of Technology in 2017. To date, he have published over 100 scientific papers, and approximately 50 with first or corresponding authorship. Meanwhile, several successful industrial and clinical translations that I have accomplished include 1) targeted platinum nanomedicine (NanoplatinTM, NC-6004) Clinical IIIb in treatment late-stage pancreatic carcinoma; 2) Nucleic acids therapeutics in pre-clinical trials.
His current research interest is emphasized on: 1) Engineering gene delivery systems: rationale in design of molecular structures for precisely condensation of nucleic acids into targeted conformation in pursuit of an appreciable extracellular and intracellular gene delivery scheme to acquire outcomes; 2) Construction of drug delivery vehicles to circumvent the pyramid of blood brain barrier:targeted transportation of biological active compounds to the neurons for treatment of Parkinson’s disease and Alzheimer diseases; 3) Development of targeted-delivery theranostic nanoparticulates for cancer therapeutics:precise control of molecular structures and ensuing formulated drug delivery nanostructures with ensemble of multiple functionalities.
1. S. Zeng, C. Chen, L. Zhang, X. Liu, M. Qian, H. Cui, J. Wang*, Q. Chen*, X. Peng. Activation of pyroptosis by organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor cancer immunotherapy. Bioactive Materials, 25, 580-593, 2023. (IF: 18.9)
2. Q. Chen, K. Osada*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka*. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials, 33, 18, 4722, 2012. (IF: 15.304)
3. Q. Chen, K. Osada*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka*. Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials, 113, 253, 2016. (IF: 15.304)
4. Z. Ge#, Q. Chen#, K. Osada*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka*. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials, 35, 10, 3416, 2014. (IF: 15.304)
5. Q. Chen#,*, R. Qi#, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong*. A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors. Molecular Therapy, 25(1), 92, 2017. (IF: 12.910)
6. H. Cui, Y. Wang, L. Chen, M. Qian, L. Zhang, X. Zheng, X. Yang, L. Chen, Y. Zhao*, Q. Chen*, J. Wang*. Chemotherapeutic potency drastically stimulated by SNAI1-knockdown based on multifaceted nanomedicine. Journal of Controlled Release, 337, 343-355, 2021. (IF: 11.407)
7. J. Xia, M. Qian, Q. Yao, Z. Meng, H. Cui, L. Zhang, Y. Li, S. Wu, J. Wang*, Q. Chen*, X. Peng. Synthetic infrared photosensitizer with multi-level targeting functions for precision photodynamic therapy. Journal of Controlled Release, 334, 263-274, 2021. (IF: 11.407)
8. J. Li#, Q. Chen#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka*, Z. Ge*. Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery. Journal of Controlled Release, 209, 77, 2015. (IF: 11.407)
9. Y. Wang, X. Zheng, J. Liu, Q. Chen*, Y. Zhao*. Convergent arrangement of sgRNA and Cas9 into CRISPRsome for transcellular trafficking. ACS Materials Letters, 4, 505-510, 2022. (IF: 11.170)
10. T. Hao#, Q. Chen#, Y. Qi, P. Sun, D. Chen, W. Jiang, K. Liu, H. Sun, L. Li, J. Ding*, Z. Li*. Biomineralized Gd2O3@HSA nanoparticles as a versatile platform for dual-modal imaging and chemo-phototherapy-synergized tumor ablation. Advanced Healthcare Materials, 8, 1901005-1901015, 2019. (IF: 11.092)
11. S. Chen#, Q. Chen#, Q. Li, J. An, P. Sun, J. Ma, H. Gao*. Biodegradable synthetic antimicrobial with aggregation induced emissive luminogens for temporal antibacterial activity and facile bacteria detection. Chemistry of Materials, 30, 1782, 2018. (IF: 10.508)
12. L. Zhang, M. Qian, H. Cui, J. Xia, S. Zeng, J. Wang*, Q. Chen*. Spatiotemporal concurrent liberation of cytotoxins from dual-prodrug nanomedicine to intracellular gradients for synergistic anti-tumor therapy. ACS Applied Materials & Interfaces, 13(5), 6053-6068, 2021. (IF: 10.383)
13. Q. Chen#,*, R. Qi#, X. Chen, H. Xiao, W. Dong*. Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression. ACS Applied Materials & Interfaces, 8, 24404, 2016. (IF: 10.383)
14. X. Han#, Q. Chen#, H. Lu, J. Ma, H. Gao*. Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative. ACS Applied Materials & Interfaces, 7, 28494, 2015. (IF: 10.383)
15. X. Chen*, H. Gu, J. Yang, S. Wu, J. Liu, X. Yang, Q. Chen*. Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles. ACS Applied Materials & Interfaces, 9, 8455-8459, 2017. (IF: 10.383)
16. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen*, H. Gao*. Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Applied Materials & Interfaces, 7, 23760, 2015. (IF: 10.383)
17. X. Yang, Q. Chen*, J. Yang, S. Wu, J. Liu, Z. Li, D. Liu, X. Chen, Y. Qiu*.Tumor-targeted accumulation of ligand-installed polymeric micelles influenced by PEGylation crowdedness. ACS Applied Materials & Interfaces, 9(50), 44045-44052, 2017. (IF: 10.383)
18. H. Cui, L, Zhang, S. Zeng, Y. Wang, Z. Li, J. Wang*, Q. Chen*. Charge reversible pro-ribonuclease enveloped in virus-like synthetic nanocapsules for systemic treatment of intractable glioma. ACS Applied Materials & Interfaces, 14(27), 30493-30506, 2022. (IF: 10.383)
19. L. Zhang, H. Cui, H. Zheng, X. Yin, J. Lin, Y. Wang, Y. Zhao, H. Li, J. Wang*, Q. Chen*. Simultaneous knockdown of immune suppressive CD47 and PD-L1 by tumor microenvironment-responsive multifaceted prodrug nanomedicine for amplified anti-tumor potencies. ACS Applied Materials & Interfaces, 15, 12864-12811, 2023. (IF: 11.407)
20. W. Wang#, S. Wu#, J Wang, Z. Li, H. Cui, S. Lin, J. Zhu, Q. Chen*. Superoxide dismutase transcellular shuttle constructed from dendritic MOF and charge reversible protein derivatives. Chemical Science, 10, 4476, 2019. (IF: 9.969)
