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3D Printing May be Used for Fish Fillets Production in the Future
Recently, Chinese first centimeter-scale tissue-like large yellow croaker fillets was successfully synthetized through technology of stem cell isolation, industrialized cultivation and structural construction, announced by the team of Professor Donghong Liu, the director of the Future Food Laboratory of the Innovation Center, and Professor Jun Chen from College of Life Science, Zhejiang University, together with the team of Academician Beiwei Zhu from Dalian Polytechnic University. Using the large yellow croaker as the research object, researchers isolated its muscle and fat stem cells, then induced muscle stem cell by regulating two types of signaling pathways. Meanwhile, a three-dimensional culture of muscle fiber bundle is made based on the bionic construction of fish muscle scaffolds, leading to the manufacture of tissue-like cell culture fish meat was realized.The cell-cultured large yellow croaker fillet has no difference with its natural equivalent after 17 days of cultivation, since they have similar smell, color and gumminess. “The high-quality protein and unsaturated fatty acids contained in marine fish have positive effects on human health. In the future, this technology may provide broader support for the supply of meat and animal protein on the human table, and it will also contribute to the protection of marine fish resources.” said Donghong Liu. This achievement was published recently, and the key technology of cell-cultured fillets was identified as the international advanced level at appraisal meeting organized by China National Light Industry Council.
05 16.2023
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Analysis and Screening Platform of Traditional Chinese Medicine
A team from the Future Health Laboratory is focusing on the forward development of traditional Chinese medicine (TCM) and establishing a world-class platform for technology innovation in TCM. It has built the first TCM ingredients unmanned screening platform with independent intellectual property rights. The team builds the Chinese largest TCM database, which includes over 1000 kinds of prescriptions, over 60000 TCM components, and more than 1000 monomer compounds and digital reference material. This is also the world’s largest TCM components database with high-throughput component screening capability. It can be utilized for determining the efficacy, pharmacological activity and toxicity of TCM synergy in various cytopathy models. The Health Laboratory has been approved as State Key Laboratory for modern creation of TCM. The team is aimed at exploring critical technologies on efficacy components of TCM, establishing knowledge library of new medicine development, designing optimal modern TCM, and evaluating druggability for the new ones of modern TCM to promote the development of innovation of TCM. In the future, the team will still devote to promoting the integration of TCM theories and modern technology, studying personal health products which can lead the development of future TCM and further encouraging “production-learning-research cooperation” to accelerate the transition from original thinking advantages to industry advantages. This team also works for making larger contribution to the development of discipline of life and health and industry upgrade in the Yangtze River Delta even the world.
11 07.2023
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Regional Development Policy Brain has been built for Intelligent Decision
Taking National Major Strategy as starting point and foothold, Regional Development Policy Brain is exploring three evolution laws concerning integration, greenization and common prosperity. It focuses on simulating future urban space, industrial pattern, green economy and common prosperity society as well. Besides, the brain is actively conducting prospective and targeted researches, promoting China Top Think Tanks to cultivate decision-making and consulting capacity, which is characterized by high dexterity, high accuracy, visualization and reliability. It is aimed at establishing decision-making system on high-quality regional development and a window to display the scientific achievement, and finally building up a interdisciplinary intelligence decision-making platform for opening and sharing.
11 28.2022
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One Research Achievement about Cxxc Finger Protein 1 from the Future Health Laboratory was Published in Nature Aging
Lately, the article “Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging” was published by team of Lie Wang from the Future Health Laboratory of Innovation Center of Yangtze River Delta, team of Han Laing from MD Anderson Cancer Center, and team of Chuan Wu from National Cancer Institute. The study found that homeostatic decline of ILC3s is mainly manifested by a decrease in CCR6+ ILC3 subsets, especially a decrease in CCR6+CD4+ ILC3s and an increase in NKp46+ ILC3s for aged mice. Homeostatic decline of ILC3s is companied by functional decline for aged mice, and a reduction in secretion of IL-22 and IL-17A restrict host’s capability of resistance to infection. Homeostatic maintenance of CCR6+ ILC3s is regulated by endogenous protective mechanisms while NKp46+ ILC3 is more affected by intestinal microenvironment and metabolic changes. In addition, the experimental data of this study reflects the impact of epigenetic regulation on homeostasis of innate lymphoid cells in aging, and indicates that ILC3s in the targeting intestine may be new breakthroughs for improving age-related infection. In recent years, population aging has been more severe. The regression of immunologic function will result in poor vaccination responses, persistent low-grade inflammation and increased infection susceptibility with aging. As a complex organ system with multiple immune cell types, the intestine shows homeostatic dysregulation and functional decline with aging. ILC3s maintain the epithelial barrier integrity by producing interleukin -22 and interleukin -17A, they also participate in adjusting the initiation and immunologic tolerance of regulatory cells (Tregs), which tightly related to intestinal dynamic equilibrium. Therefore, exploring homeostatic and functional changes of ILC3s is of great significance for improving health at the old age.
08 09.2023
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The Latest Findings on “Mental Health Penalties of Having a Child” was Publish in npj Mental Health Research
Recently, the paper “Mental health penalties of having a child: findings from the China family panel studies” co-authored by Xinjie Shi, the double-employed scholar from the Common Prosperity Research Center, Innovation Center of Yangtze River Delta, and Dr. Yu Shen from Nanjing University of Finance & Economics, was accepted and released online by npj Mental Health Research, one of the Nature-branded journals. This study is one of the research findings on urban-rural opportunity equity. It has been This study is a supplement to available articles on childbearing penalty, most of which has focused on the impact of labor market outcomes but paid little attention to impact of gender differences on men's and women's mental health. This study found that childbearing penalty in terms of mental health brought by childbearing is also substantial, which is likely associated with the childbearing penalty in labor market performance. This is marked by fewer opportunities and lower income and physical health for women. The study’s findings suggest that to achieve the United Nation’s Sustainable Development Goals 3 and 5, more attention should be directed to women’s mental health. While the macro-level association between demographic transition and economic growth has been studied in detail, few studies have focused on the micro-level implications for women. When countries that face the problem of the so-called “low-fertility trap” attempt to adopt multiple tools to stimulate the birth rate for economic growth, they must simultaneously consider the implicit burden on women. This requires not only efforts from governments to enterprises, individuals and civil society, but also a mixed tool of the supportive healthcare system and labor market policies (e.g., eliminating gender discrimination).
06 20.2023
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The Achievement from the Future Health Laboratory was Select as “Top 10 Academic Progress in Traditional Chinese Medicine of Year 2022”
On February 25, 2023, the Conference of Top 10 Academic Progress in Traditional Chinese Medicine of Year 2022 was held in Beijing, which was sponsored by the China Association of Chinese Medicine. The research finding “Revealing the Scientific Connotation of Activating Blood Circulation Herbs Protecting Cardiac Muscle Through Syncretic Single-Cell Omics Technology”, which is from the team of Xiaohui Fan and Yi Wang from the Future Health Laboratory, was listed as one of academic progress in new technology assisting in interpreting efficacy of Traditional Chinese Medicine (TCM) such as single-cell Proteomics and so on.The team of Xiaohui Fan and Yi Wang from the Future Health Laboratory, together with Tianjin University of Traditional Chinese Medicine, developed a series of new single-cell analytical tools, which are targeted at analyzing bottlenecks on scientific principle of TCM in treating disease. The study found that immune cell has dynamic regulation effect on damage repair after myocardial infarction. Taking TCM such as Rhodiola rosea L. and Salvia miltiorrhiza Bunge as objects, the study also elucidated deeply the molecular mechanism how Tanshinon IIA regulates immune cell subsets to narrow the range of myocardial infarction. It also clarified the mechanism of herbacetin in Rhodiola rosea L. inhibiting SGK1 to resist cardiac hypertrophy. Correlational researches provide new technologies and examples for expounding clearly the intension of effectiveness of TCM. Related papers were published in 2022 on Nature Communications, Advanced Science, Small Methods and China Journal of Chinese Materia Medica, and 4 of them were selected as cover or Editors’ Highlights. Three patents were authorized as well.
02 27.2023
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The Article of Professor Jianchun Fang from the Future Regional Development Laboratory was Conferred “Wiley Top Cited Article 2021-2022”
On February 21, 2023, the article “Globalisation, economic uncertainty and labour market regulations: Implications for the COVID-19 crisis” published by Prof. Jianchun Fang, deputy director of the Future Regional Development Laboratory (Green Development Research Center) received a certificate from Wiley, a top three publishers in the world. This certificate is a strong endorsement and proof for quality of academic achievements since it is one of the ultimate accolades for citations. The article investigates the effects of globalization and economic uncertainty on labor market regulations during the COVID-19 pandemic. The research findings provide theoretical and empirical basis for formulation of labor market policies and promotion of labor market flexibility, especially for implementation of several policies like flexible labor market. After being cited by International Atomic Energy Agency, Prof. Jianchun Fang obtained the certificate from Wiley for the global top cited paper, which is the new breakthrough in publication of papers for the Future Regional Development Laboratory. This has laid a foundation for the laboratory on application of theoretical achievements in the future.
02 24.2023
