-
The Future City (Industrial Intelligent Manufacturing) Laboratory of the Smart Oasis Innovation Center has successfully passed the feasibility study
In order to solidly promote the construction of the future laboratory of Zhejiang University Yangtze River Delta Smart Oasis Innovation Center and promote the formation of an industrial intelligent manufacturing industry ecosystem in the Yangtze River Delta region, on October 16, 2024, the Smart Oasis Innovation Center held a feasibility study meeting for the entry of future urban (industrial intelligent manufacturing) laboratories. The demonstration meeting was presided over by Professor Zhu Lizhong, an academician of the CAE Member and the chief scientist of the Smart Oasis Innovation Center. Professor Zeng Bin, an academician of the CAE Member and the chief scientist of China Minmetals Group Co., Ltd., a professor level senior engineer, Zhu Zhongyi, a national survey and design master and chief engineer of Beijing Architectural Design and Research Institute Co., Ltd., and Professor Zhang Tuqiao, a super expert of Zhejiang Province and consultant of the Smart Oasis Innovation Center, were specially invited to participate in the demonstration meeting.The expert group listened to a report from the relevant person in charge of the Future City (Industrial Intelligent Manufacturing) Laboratory on the laboratory construction plan. After questioning and thorough discussion, it is believed that the construction of a future city (industrial intelligent manufacturing) laboratory is of great significance in promoting China's green and intelligent engineering construction. The laboratory's organizational structure, team building, and target tasks are reasonable and feasible, and the laboratory construction plan is unanimously agreed upon. It is suggested that the laboratory should face market demand, further focus on the key construction direction of the laboratory, strengthen collaborative research and development of key core technologies, create several major landmark products and implement them, and contribute to the formation of an oasis force for the industrial intelligent manufacturing industry ecosystem in the Yangtze River Delta region.Extended ReadingThe Future City (Industrial Intelligent Manufacturing) Laboratory focuses on research directions such as green and intelligent construction of high-performance integrated materials, complete sets of industrial intelligent construction equipment, etc. Through interdisciplinary convergence, it develops high-performance and structurally functional integrated cement-based composite materials, mobile automatic spraying high-performance cement-based composite construction robots, fixed concrete and metal 3D hybrid multi axis printing devices, etc., and promotes their application. The construction of the laboratory will provide an innovative technology platform for achieving green and intelligent national engineering construction, and provide strong technical support for building a strong quality and manufacturing country.
10 18.2024
-
Professor Liu Xiangrui's team from the Future Health Laboratory, in collaboration with China Resources Zizhu Pharmaceutical, has approved the clinical trial of class 2.2 new drug ZP036
On September 4, 2024, the innovative formulation team led by Professor Liu Xiangrui from the Future Health Laboratory of the Yangtze River Delta Smart Oasis Innovation Center at Zhejiang University, in collaboration with China Resources Zizhu Pharmaceutical, obtained clinical implied permission from the National Medical Products Administration (CDE) to conduct clinical research on the 2.2 class new drug ZP036.ZP036 is used to treat functional disorders caused by progesterone deficiency, including menstrual disorders caused by ovulation dysfunction, dysmenorrhea and premenstrual syndrome, bleeding (caused by fibroids, etc.), premenopausal disorders, menopause (used for estrogen supplementation therapy), and also helps with pregnancy. ZP036 is an improved new drug that has not been marketed domestically or internationally, with independent intellectual property rights, and is expected to break the current market dominance of imported drugs in this category. Wei Mengying, a specially appointed researcher in the innovative formulation team of the Smart Oasis Innovation Center, and Lin Yuanyuan, an engineering specialist, participated in the research and development of this new drug.Team Introduction:The innovative formulation team is led by Professor Liu Xiangrui and consists of more than ten young research backbones, focusing on the application and transformation research of innovative drug formulations, oral dietary supplements, and pharmaceutical excipients. At present, the team has established joint research institutions with multiple companies such as China Resources Sanjiu Pharmaceutical Co., Ltd. and Shanghai Xiaoya Biotechnology Co., Ltd. Through systematic measures of interconnectivity and complementarity, the team and enterprises work together to tackle challenges, striving to efficiently and quickly transform scientific research achievements into pharmaceutical products that serve the public.
09 07.2024
-
Engineering Structures | Future City (Smart City) Laboratory Engineering Simulation Software Team Proposes a New Engineering Unit for Layered Structure Modeling
Recently, the engineering simulation software team of the Future City (Smart City) Laboratory at Zhejiang University's Yangtze River Delta Smart Oasis Innovation Center published an innovative article titled Multi Layered Solid Element for Seismic Analysis of Rubber Bearings Considering Stress Continuity Based on Finite Particle Method in the top journal Engineering Structures in the Engineering Technology Zone 1. Yao Junjie, a doctoral student at the Future City (Smart City) Laboratory of the Smart Oasis Innovation Center, is the first author of the paper, and Zheng Yanfeng, a dual hired scholar, is the corresponding author of the paper.The paper proposes a novel layered solid element based on the Finite Particle Method (FPM) for modeling layered structures, which is suitable for high-performance simulation of laminated rubber bearings in isolation systems and can be effectively used for seismic analysis of engineering isolation structures.Base isolation is a highly effective seismic strategy for structures. Its core principle is to install flexible devices at the bottom of the structure to concentrate the horizontal displacement of the structure under earthquake action on the isolation layer at the bottom, thereby reducing the acceleration and internal force response of the upper structure. For common seismic isolation bearings such as rubber bearings, traditional simplified modeling methods ignore the layered structure of rubber bearings, which has limitations in universality and scalability. Fine modeling, due to the generation of a large number of nodes and elements, leads to high computational costs.This study proposes a layered solid element based on the finite particle method, which balances the accuracy and efficiency of support modeling. It can conveniently apply various universal three-dimensional material constitutive models (such as rubber hyperelastic constitutive model and steel bilinear constitutive model) to the material layers inside the element. The study extends the traditional layered Zigzag shape function to three-dimensional space, ensuring the continuity of interlayer forces in materials, and efficiently simulating the deformation process of layered structures with a single unit. Compared with refined multi-body models, the computational acceleration ratio is 19 times. Based on layered solid units, corresponding calculation models were proposed for two types of bearings, natural rubber bearings (NRBs) and lead rubber bearings (LRBs), and the layered solid models were verified through bearing experiments to accurately capture the hysteresis behavior of the two types of rubber bearings.This layered solid unit provides an innovative solution for efficient simulation of complex rubber bearings in seismic isolation systems. With the continuous advancement of computing hardware and parallel technology, the application of layered solid elements in large-scale structural seismic time history analysis will become more extensive and in-depth. In addition, by combining intelligent algorithms and data-driven methods, layered solid units are expected to achieve parameter optimization design and rapid simulation of rubber bearings, in order to improve the design efficiency of engineering structures. This method also has the potential for expansion and can be applied to other engineering structures with layered characteristics, opening up more possibilities for structural engineering simulation and design.This study was supported by the National Key Research and Development Program (2023YFC3805600) and the National Natural Science Foundation of China (522380015237820352308218 and 52008366).Paper link:https://doi.org/10.1016/j.engstruct.2024.118713Author Profile:Yao Junjie, a doctoral student at the School of Architecture and Engineering, Zhejiang University, is a core member of the engineering simulation software team at the Future City (Smart City) Laboratory of the Zhejiang University Yangtze River Delta Smart Oasis Innovation Center. He mainly engages in research on structural seismic reduction and isolation simulation, and has participated in the National Natural Science Foundation Key Project (52238001) and multiple National Natural Science Foundation Youth Science Fund projects. He has published three academic papers in Engineering Structures, Journal of Building Structures, and Engineering Mechanics.Zheng Yanfeng is a specially appointed researcher and doctoral supervisor at the School of Architecture and Engineering, Zhejiang University. He is also a double hired scholar at the Future City (Smart City) Laboratory of Zhejiang University's Yangtze River Delta Smart Oasis Innovation Center. He graduated with both a bachelor's and doctoral degree from Zhejiang University and is a visiting scholar at Kyoto University in Japan. My research interests include complex structural behavior, strong dynamic load effects on structures, deep spatial structures, artificial intelligence, and computational mechanics. Hosted 3 projects funded by the National Natural Science Foundation of China (including key sub projects), 1 project funded by the Zhejiang Provincial Natural Science Foundation, participated in 4 national level scientific research projects, contributed to the compilation of 1 national industry standard, and worked in Engineering Structures Thin-Walled Structures、Journal of Constructional Steel Research、 More than 30 academic papers have been published in authoritative domestic and foreign journals such as Journal of Architectural Structures and Engineering Mechanics, and the results have been applied in projects such as the structure of the Jiangmen Neutrino Experiment detector, a national scientific facility. Serving as a member of the Journal of Building Engineering Structures、Advances in Structural Engineering、 Reviewer for journals such as Journal of Shanghai Jiao Tong University, Journal of Earthquake Engineering, and Vibration and Shock.Journal Introduction:Engineering Structures is an internationally recognized top academic journal in the field of civil engineering, founded by Elsevier BV Publishing Group in 1978. It is a top journal in JCR-1 and the first district of the Chinese Academy of Sciences, with a current impact factor of 5.6. This journal is renowned for its comprehensive research in the field of civil engineering, covering a wide range of research topics including but not limited to foundation engineering, earthquake engineering, structural dynamics, structure fluid soil interactions, wind engineering, structural health monitoring, structural optimization, and data-driven analysis methods.
09 02.2024
-
Future Health Lab team reports new method for inferring intercellular communication in Nat Commun SpaTalk
On July 30, 2022, Prof. Fan Xiaohui's team at the Future Health Laboratory of the Yangtze River Delta Innovation Center of Zhejiang University, in collaboration with Prof. Xu Xiao's team at the First People's Hospital of Hangzhou affiliated to the Medical College of Zhejiang University, and Prof. Chen Huajun's team at the School of Computer Science of Zhejiang University, published an online research paper in the journal Nature Communications Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk. Intercellular communication, also known as intercellular interaction, refers to the process by which one cell generates a signal that is transmitted to another cell through a medium, which in turn regulates the target cell and produces a series of biological effects such as growth, proliferation, differentiation, and apoptosis. Accurate identification of intercellular communication is a key link in understanding disease development and developing interventional drugs, which is increasingly emphasized by the industry. With the development of recent years, the rapid development of spatially resolved transcriptomics sequencing technology has been widely used to explore the spatial heterogeneity of cells, as it realizes both transcriptome sequencing and preserves the spatial location information of cells and their genes. Currently, spatial transcriptome sequencing technologies are divided into two main categories according to their principles. The first category is based on high-throughput RNA imaging technologies, including STARmap, MERFISH, seqFISH, etc., which realize spatial transcriptome sequencing at single-cell resolution; the second category is based on spatial barcoding technologies, including 10X Visium, Slide-seq, HDST, Stereo-seq, etc., which realize spatial regions of whole transcriptome sequencing. . Obviously, the rapid development of spatial transcriptome sequencing technology provides technical support and data sources for studying the spatial heterogeneity of intercellular communication, and how to utilize spatial transcriptome data to infer intercellular communication has become an important challenge in related fields. In this study, we developed SpaTalk, a spatial transcriptome sequencing data-based method for inferring intercellular communication, by introducing artificial intelligence algorithms such as knowledge graph, non-negative linear regression, and random walk, etc. The method integrates the spatial proximity principle of ligand-receptor and co-expression of ligand-receptor and downstream targets, and performs graph network and knowledge graph modeling and scoring on spatially significant ligand-receptor and signaling pathways in the receptor cells, respectively. knowledge graph modeling and scoring to infer ligand-receptor interaction-mediated intercellular communication in a restricted space. SpaTalk is divided into two steps: (1) The first step is to use the single-cell transcriptome sequencing data as a reference map to resolve the cellular composition in the spatial transcriptome data, and then reconstruct the single-cell map with known cell types and spatial coordinates. For single-cell resolution idling data, SpaTalk identifies the type of each single cell in the idling data through non-negative linear regression; for regional resolution idling data, SpaTalk identifies the proportion of different cell types in each region through non-negative linear regression, and thus utilizes spatial mapping to reduce the single cells in the reference atlas to different spatial regions. (2) The second step is to model ligand-receptor-downstream transcription factor-target genes using knowledge mapping, and filter ligand-receptor interaction pairs that are spatially significantly adjacent and activated by downstream signals of the receptor cells through algorithms such as substitution test and random walk. The results show that SpaTalk can not only accurately resolve the cell proportions of the baseline test data, which is better than other deconvolution methods; it can also accurately infer the ligand-receptor pairs that mediate spatial cell-to-cell communication and their activated downstream signaling pathways, which is more accurate than other methods for inferring intercellular communication. Compared with other existing methods, SpaTalk enables the comparison and visualization of intercellular ligand-receptor interactions at the single-cell level for the first time, and the application cases further demonstrate the unique advantages of SpaTalk in resolving the key intercellular communications in normal physiological and pathological processes at the spatial single-cell resolution. This research was funded by the National Natural Science Foundation of China, the National Key Research and Development Program of China, and the Natural Science Foundation of Zhejiang Province, and supported by Aliyun.
10 11.2023
-
The First Roadshow of Validated Projects for Transformation of Innovative Achievements was Successfully Held
In order to build a platform for displaying and exchanging science and innovation achievements, and to boost the efficient transformation and landing of the achievements, on August 10, 2023, Innovation Center of Yangtze River Delta, Zhejiang University successfully held the first roadshow conference for the transformation of innovative achievements into validated projects in Xiangfudang Science and Innovation Green Valley. Lin Weilian, Director of Zhejiang University's Domestic Cooperation Office and Secretary of the Party and Work Committee of the Yangtze River Delta Wisdom Oasis Innovation Center, and Li Zhijie, Deputy Director of the Administrative Committee of Jiashan Demonstration Zone, attended the event and delivered speeches. Relevant leaders from Jiashan County Economic and Information Bureau, Human Resources and Social Affairs Bureau, Science and Technology Bureau, Luoxing Street, and team members of Wisdom Oasis Innovation Center attended the event. The event specially invited 11 senior experts from government agencies, financial institutions, industry leading enterprises as judges. After self-declaration, pre-screening and other links, 37 project teams from domestic first-class universities, research institutions and enterprises and institutions to participate in the activities and roadshow demonstration. In the roadshow session, 37 teams of transformation and validation projects were presented in two venues. In the comprehensive venue, 25 transformation verification projects involving advanced equipment manufacturing, new energy, new materials, construction engineering, big data, culture and tourism and other fields were presented; in the medical and healthcare venue, 12 projects involving new drug development, new therapeutic applications, medical device research and development and other fields were presented. The evaluation experts asked questions and scored the roadshow projects in terms of technical innovation, feasibility and market prospect, and made targeted suggestions to help the projects to be revised and improved. Since its establishment, the Wisdom Oasis Innovation Center has been focusing on the transformation of achievements as a key task, established the Innovation Achievement Transformation and Verification Center, constructed the five systems of innovation achievement transformation and verification consisting of the project source system, evaluation system, service system, risk control system, and growth system, and made great efforts to play the role of a bridge to enable the scientific and technological achievements and the market for the products of each other, and strived to build a new business model in the core area of the Yangtze River Delta. It strives to build a preferred place for innovation transformation in the core region of the Yangtze River Delta. At present, the first batch of transformation and verification projects have been completed, the first funded project plasma tumor treatment equipment has been incubated in the future innovation park of Zhejiang University National University Science and Technology Park in Guigu Park. The second batch of projects for the whole country has also been completed, a total of 56 internal and external projects have been collected, of which 37 have been shortlisted for this roadshow. The next step is that the Innovation Center will conduct further evaluation and screening based on the performance of each transformation verification project in this roadshow conference, select the best projects for funding, and prioritize the more mature projects to be recommended to Jiashan for landing. Transformation of results for development, open cooperation to win the future. Wisdom Oasis Innovation Center adheres to the open development of results transformation, by expanding the circle of friends, increasing the source of projects, doing a good job of aggregation and catalyst, and releasing the kinetic energy of science and innovation. We sincerely welcome science and innovation teams at home and abroad to declare fruit transformation validation projects, relying on the good platform, resources and services provided by the Innovation Center, to promote high-quality science and innovation achievements to embark on a new journey of transformation nirvana.
10 11.2023
-
Doing pure things with simple minds
What we need are simple entrepreneurs with pure minds, the first time I heard this was at the rally meeting for the labs of center on July 6th 2022, said a staff. A professor present emphasized that the center should introduce better policies and provide better treatment and conditions in order to attract scholars to work here. On hearing this, Mr.Lin, secretary of the center said emotionally, What you just said, the center is not yet available for the time being, but we firmly believe that there will be one in the future. What mostly needed at the moment is simple entrepreneurs with pure minds. Mr.Lin's words gave me a great shock, and the wordssimple entrepreneur is also deeply rooted in my heart, and I can't help but ask myself: what is the spirit of simplicity? Why we need the simple entrepreneurs? When it comes to simplicity, the first thing that comes to mind is hardship and simplicity. Ask yourself, can the conditions at the centre be called hardship? The answer is just the opposite. The centre has a unique natural beauty. The Centre is situated in the Xiangfudang Wetland in Jiashan, and as far as the eye can see from the office, there is either a wide lake or boundless rice fields. The descending clouds，align themselves with the solitary bird on their flight in view, while the tranquility of the water blends in with the dimension of the sky into the same hue. The scenic beauty has become a daily routine in the workplace. The centre has first-class hardware conditions. The laboratory is built according to high standards, and the construction of general area, clean area and office area is in line with the first-class design and construction standards. The investment in instruments and equipment is even more extraordinary. The centre is full of future-oriented and future-touching spirit. The Centre has a profound humanistic heritage. Adjacent to Xitang, a thousand-year-old town, its cultural deposits and the spirit of seeking truth and innovation of ZJU people are integrated and complement each other, which has become a strong cardiac agent to nourish the Centre, and also a distinctive undertone for the staff of the Centre to strive for the best, innovate and strive for advancement, and point to the first-class. Simple emotions come from strong beliefs As the question of Zhu Kezhen said, we always reflect on what we are doing in ZJU. What do we ZJU people want to do when we leave Hangzhou campus and come to Jiashan Xiangfudang Park? Promoting the integrated development of the Yangtze River Delta is a major strategy planned, deployed and promoted by General Secretary Xi Jinping. Jiaxing City, Jiashan County and Zhejiang University to join hands to build this high-capacity innovation platform, is in the joint efforts to promote the integration of high-quality development of the Yangtze River Delta, and strive to build a national strategic scientific and technological forces and regional innovation source. With the responsibility on our shoulders and the mission in our bodies, we should be firm in our beliefs and move forward with courage and perseverance. Simple emotions come from practical commitment We are not a group of hot-blooded young people with blind confidence, we have both experienced party and government members and academically sophisticated experts and scholars in our team. The persistent pursuit of intelligent Chinese medicine stack research and development, laboratory construction and renovation of forgetfulness, the opening ceremony of the elaborate planning, systematic innovation of the overall planning, the pursuit of perfection in the details of the polishing ...... keep love, keep improving, we are in the ordinary work position, with the practical work to take responsibility for the pursuit of success.Looking up to the stars and keeping their feet on the ground, the Centre's entrepreneurs will continue to do pure things with simple minds.
10 11.2023
-
Class of 2023 Graduate Student Commencement Ceremony Held
In the fruitful autumn season, in the innovation surging green valley of science and innovation, Innovation Center of Yangtze River Delta, Zhejiang University in the first batch of new graduate students.On the morning of September 24, 2023, the commencement ceremony of the 2023 graduate students of Zhejiang University Yangtze River Delta Wisdom Oasis Innovation Center was held grandly in Jiashan. Chen Ping, Deputy Director of Graduate Admission Office of Zhejiang University, Zhao Zhangyao, Vice Dean of College of Engineers, Yang Huirong, Deputy Secretary of Party Committee and Secretary of Discipline Inspection Committee of College of Pharmaceutical Sciences, Wang Yi, Vice Dean of College of Pharmaceutical Sciences, Cao Huiming, Standing Committee Member of CPC Committee of Jiashan County, Deputy Secretary of CPC Working Committee of the Demonstration Zone and full-time Deputy Director of the Management Committee, and Li Zhijie, Deputy Director of the Demonstration Zone, Lin Weilian, Director of the Office of Domestic Cooperation of Zhejiang University and Secretary of the Party Committee of the Intelligent Oasis Innovation Center, and all the members of the team of the Innovation Center, The head of the Future Laboratory, as well as the head of the Youth League Committee of relevant colleges of Zhejiang University and the new graduate students attended the opening ceremony. During the ceremony, faculty members wore the university emblem for the new students. The commencement ceremony for the Class of 2023 graduate students of Innovation Center of Yangtze River Delta, Zhejiang University ended successfully with the loud and clear school song of Zhejiang University. After the ceremony, Prof. Fan Xiao Hui, Director of the Center, gave the first lesson of Oasis to the new students. He systematically introduced the basic situation of Smart Oasis and the progress of its construction from the aspects of strategic background, strategic positioning, overall planning, development history and key work, and students' cultivation, in order to help all the new students to better understand Smart Oasis and integrate into Smart Oasis.
10 11.2023
